Jans Alzate Morales Química computacional, reactividad enzimática e ingeniería de proteínas, interacción ligando-proteína.
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2015 a 2019
Designing chemical poly-bullets for nicotinic acetylcholine receptors and monoamine transporters (SERT, NET and DAT). A poly-pharmacology approach to understand the nicotine addiction and withdrawal syndrome mediated by multiple receptor targets
Participó como Associate researcher en FONDECYT Regular No. 1150615Nicotine, the main alkaloid from the tobacco plants is a potent psychoactive drug that induces euphoria and addiction. This alkaloid binds to a particular class of ligand-gated...
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2014 a 2017
Biotransformation Processes Catalyzed by Ligninolytic Enzymes from Phanerochaete chrysosporium: Rational Protein Design from Computational calculations and site-directed mutagenesis studies.
Participó como Principal researcher en FONDECYT Regular No. 1140618 -
2013 a 2017
Fishing For Complements: Design Of Compounds That Simultaneously Interact With Monoaminergic Proteins And Nicotinic Receptors, Based On Similarities Between Their Ligand Binding Sites
Participó como Associate researcher en FONDECYT Regular No. 1130185 -
2013 a 2016
Insights Into The Structural Basis Of The Interactions Between Camp-Dependent Protein Kinase (PKA) And Its Substrates: Development Of Predictive Molecular Models And Testing In The Study Of The Interactions Between PKA And Potassium Channel Akt2
Participó como Associate researcher en FONDECYT Regular No. 1130141 -
2012 a 2014
Concurso de Apoyo a la Formación de Redes Internacionales entre Centros de Investigación
Participó como Coinvestigador en CONICYT No. ####Proyecto de cooperación internacional con el Max Planck Institute of Plant Physiology en Potsdam, Alemania.
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2010 a 2013
Understanding the Protein-Ligand Binding Phenomena through hybrid calculation approaches and other Computational Methods
Participó como Principal researcher en FONDECYT Iniciacion No. 11100177